• Arch Orthop Trauma Surg · Dec 2014

    The effect of diclofenac on matrix metalloproteinase levels in the rotator cuff.

    • Haluk Cabuk, Arzu Avci, Hüseyin Durmaz, Fatmagül Kuşku Cabuk, Fatih Ertem, and I Muhittin Şener.
    • Department of Orthopedics and Traumatology, Okmeydanı and Research Hospital, Şişli, Turkey, halukcabuk@hotmail.com.
    • Arch Orthop Trauma Surg. 2014 Dec 1;134(12):1739-44.

    IntroductionMatrix metalloproteinases (MMPs) are involved in physiological events such as restructuring of the tissue, morphogenesis, wound healing and normal developmental process. Use of diclofenac sodium following rotator cuff repair can disrupt healing of tendon through acting on MMPs.Materials And MethodsSupraspinatus tendons of rats (n = 84) were detached from their insertion on humerus, and repaired to anatomic footprint. Rats were divided into study group (n = 42) and control group (n = 42). Study group received a dose of 1 mg/kg daily diclofenac sodium subcutaneously. The rats were killed at weeks 1, 3 and 6, and seven rats from each groups were included in biomechanical and immunohistological examinations. Immunohistological staining of MMP-2, MMP-3 and MMP13 were used.ResultsMaximum load was reduced in the study group at the end of week 1 (8.76 vs. 5.28 N) (p = 0.01). MMP-3 level was statistically significantly lower in the study group at the end of week 1. MMP-13 level and stiffness decreased towards week 6 in the study group while in the control group the level of MMP-2 decreased towards week 6.ConclusionDiclofenac has an impact on the levels of MMP-2, MMP-3 and MMP-13, which are needed for normal healing process, and it can also lead to disruption of tendon healing.

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