• Huaiyan Jiang, Yang Gao, Zhen Chen, and Hongxia Xu.
• Department of Ophthalmology, The Affiliated Kunhua Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China.
• Medicine (Baltimore). 2021 Apr 9; 100 (14): e25392e25392.

BackgroundMatrix metalloproteinase-2 (MMP-2) polymorphisms have been considered as risk factors of cataracts, but the results still remain controversial. In this study, we have performed a systematic meta-analysis to evaluate the association between MMP-2 polymorphisms and cataract risks.MethodsPublished literature was retrieved from Wanfang, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Chongqing VIP Chinese Science and Technology Periodical Database, PubMed, Embase, and Web of Science databases. The case-control studies that explored the association between MMP-2 polymorphisms and cataract risks were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model.ResultsThis study could provide high-quality and evidence-based medical evidence for the correlation between MMP-2 polymorphisms and cataract risks.ConclusionThe study could provide updated evidence for the evaluation of the relationship between MMP-2 polymorphism and cataract risk.Ethics And DisseminationThe private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not available. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.Osf Registration NumberDOI 10.17605/OSF.IO/KU9NE.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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