• Zhongguo Ying Yong Sheng Li Xue Za Zhi · Nov 2001

    [The effect of renal ischemic preconditioning on the myocardial ischemic/reperfusion injury in rabbits].

    • Y J Wang, Y Z Lu, and X L Wang.
    • Department of Cardiology, Changzhi Medical College, Changzhi 046000, China.
    • Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001 Nov 1; 17 (4): 366-9.

    AimTo investigate whether renal ischemic preconditioning could protect myocardium from ischemic-reperfusion injury.MethodsThirty-two adult white rabbits were randomly divided into four groups: group sham operation (SO), myocardial ischemic-reperfusion (I/R), classical ischemic preconditioning (CIPC) and renal ischemic preconditioning (RIPC). Changes of left ventricular functions, myocardial infarct size, myocardial ultrastructure and cardiac arrhythmia were observed.ResultsRIPC and CIPC could reduce the myocardial infarct size and the attack rate of arrhythmia (P < 0.01 vs I/R); improve the left ventricular functions (P < 0.01 vs I/R) and minimized the ultrastructure injury of I/R myocardium.ConclusionThe RIPC might elicit a myocardial protection against ischemic-reperfusion injury, which is similar to the effect of CIPC.

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