• Gwan Gyu Song, Jae-Hoon Kim, and Young Ho Lee.
• Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
• Gene. 2013 Jul 15; 524 (1): 72-8.

ObjectiveThe aim of this study was to determine whether ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms confer susceptibility to asthma in different populations.MethodsWe performed a meta-analysis on the association between the ADAM33 S2, ST+4, F+1, S1, and V4 polymorphisms and asthma.ResultsThirteen studies in ten reports, which included 4942 patients and 7933 controls, were available for the meta-analysis. Meta-analysis stratified by ethnicity indicated an association between the ADAM33 S2 2 allele and asthma in Europeans (OR=0.912, 95% CI=0.851-0.977, p=0.009). Meta-analysis revealed an association between asthma and the ADAM33 ST+4 2 allele (OR=0.783, 95% CI=0.762-0.999, p=0.048). Stratification by ethnicity indicated an association between the ADAM33 ST+4 polymorphism and asthma in Asians. Stratification by age indicated an association between the ADAM33 ST+4 2 allele and asthma in adults (OR=0.863, 95% CI=0.782-0.964, p=0.008). However, no association was found between asthma and the ADAM33 F+1, S1, and V4 polymorphisms.ConclusionsThis meta-analysis demonstrates that the ADAM33 S2 polymorphism confers susceptibility to asthma in Europeans and the ADAM33 ST+4 polymorphism is associated with asthma in Asians and adults.Copyright © 2013 Elsevier B.V. All rights reserved.

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