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J. Neurol. Neurosurg. Psychiatr. · Jan 2001
Case ReportsPrimary diffuse leptomeningeal gliomatosis simulating tuberculous meningitis.
- J H Rees, N Balakas, A Agathonikou, S F Hain, G Giovanonni, C P Panayiotopoulos, M Luxsuwong, and T Revesz.
- University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK. j.rees@ion.ucl.ac.uk
- J. Neurol. Neurosurg. Psychiatr. 2001 Jan 1; 70 (1): 120-2.
AbstractThree patients are reported on who presented with communicating hydrocephalus due to presumed tuberculous meningitis. Subsequent clinical deterioration despite antituberculous chemotherapy prompted reassessment with FDG-PET scanning and meningeal biopsy in one case and repeat CSF cytology with special staining in the second. The third patient died and postmortem confirmed a diagnosis of primary diffuse leptomeningeal gliomatosis. In the first two patients, MRI of the entire neuraxis showed no evidence of a primary intraparenchymal tumour. These cases emphasise the need for repeated reassessment in patients with culture negative lymphocytic meningitis. In addition, this is the first report of FDG-PET scanning in leptomeningeal gliomatosis.
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