• Rui Wang, Xuesong Song, Yan Chen, Na Wang, and Jinguo Wang.
• From the Department of Computer Network (Wang R), Technology School, Jilin Business and Technology College, Changchun, Jilin; from the Department of Anesthesiology (Song, Chen, Wang N); and from the Department of Urology (Wang J), The First Hospital of Jilin University, Changchun, China.
• Saudi Med J. 2021 Jul 1; 42 (7): 707-713.

ObjectivesTo compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).MethodsA literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.ResultsThe final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.ConclusionsTropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368.Copyright: © Saudi Medical Journal.

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