Saudi Med J
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Multicenter Study Observational Study
Multivariable prognostic model for dialysis patients with end stage renal disease: An observational cohort study of Pakistan by external validation.
To develop an externally validated multivariable prognostic model for an underprivileged dialysis population. ⋯ We developed an externally validated model that contained 5 routinely collected prognosticators and confirmed its calibration and discrimination abilities in obtaining reliable prognostic estimates in developing countries. The model will assist clinicians in deciding the prognosis of dialysis patients. The application of this model in different clinical settings of developing countries can indicate interesting findings regarding public health.
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To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV). ⋯ Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368.
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To investigate whether gastric Helicobacter pylori (H. pylori) infection is associated with the progress of nonalcoholic fatty liver disease (NAFLD) in Dali city, China. ⋯ A positive correlation is identified between H. pylori infection and NAFLD.
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To optimize an enzyme-linked immunosorbent assay (ELISA) for measuring the HspX protein (α-crystallin) levels and then evaluate its correlation with the accumulation of lipid bodies in Mycobacterium bovis (M. bovis) during hypoxia and exposure to nitric oxide. ⋯ The optimized ELISA protocol in this study can detect HspX protein levels in M. bovis growing in normal and hypoxic environments. Importantly, hypoxia led to enhanced expression of HspX protein, which correlated with the enhanced production of lipid bodies. Lipid body production is a survival strategy of pathogenic mycobacteria.