• M Kumar, D N Rao, S Mohanty, and S Bhoi.
• 1Department of Emergency Medicine, JPN Apex Trauma Center, AIIMS, New Delhi, India 2Biochemistry, AIIMS, New Delhi, India 3Stem Cell Facility, AIIMS, New Delhi, India.
• Shock. 2015 Oct 1;44 Suppl 2:25.

IntroductionTrauma injury and hemorrhagic shock frequently leads to the imbalance of immune system known as Systemic Inflammatory Response syndrome (SIRS) and is connected to the morbidity or mortality. Pro and Anti- inflammatory, which play a significant role in the development of multiple organ failure (MOF). This study investigates the serum cytokines levels in patients with trauma hemorrhagic shock and the association of these cytokines with clinical outcome.MethodsProspective cohort study in 70 patients with trauma hemorrhagic shock admitted to the emergency department, level 1 trauma centre. Peripheral blood samples were collected for in each patient for determination of serum cytokines concentration. Samples were obtained within 8 h of post injury (on arrival), day 3 and 7 with T/HS patients. Standard resuscitation techniques as per Advance Trauma Life Support were used in each patient. Clinical and laboratory data were prospectively collected.ResultsHigh concentrations of circulating IL-6, IL-10, IL-8, IL-12, (p < 0.05) were detected in a trauma hemorrhagic shock as compared with healthy control group. At study entry, IL-8 concentrations were higher in non- survivors as compared with survivors. Increased IL-8 value was an indicator of mortality in patients with trauma hemorrhagic shock.ConclusionIn trauma hemorrhagic shock, increased IL-6, IL-10, IL-8, IL-12 are detected while compared to normal healthy control. In these patients, increased IL-8 value in nonsurvivors as compared to survivors. This study suggests a much higher degree of activation of immune-inflammatory in T/HS than in normal healthy control. Increased IL-8 values were found to be reliable markers of mortality following T/HS.

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