• Journal of anesthesia · Mar 1996

    Effects of osmotic pressure on intrathecal and epidural lidocaine anesthesia.

    • T Minami, N Koyama, and Y Amakata.
    • Department of Anesthesiology, Shiga University of Medical Science, Seta, 520-21, Otsu, Japan.
    • J Anesth. 1996 Mar 1;10(1):39-43.

    AbstractLidocaine (1%), either in plain distilled water or in 10% dextrose, was intrathecally or epidurally administered to urethane-chloralose anesthetized cats. Electrical stimulation was applied to the gracile tract at a cervical level, and the resultant antidromic compound action potentials were recorded from the sural nerve. Lidocaine dissolved in plain distilled water was more effective than lidocaine dissolved in 10% dextrose solution in suppressing the compound action potentials. Lidocaine-free plain distilled water or dextrose solution caused partial suppression of the compound action potentils. The suppression was more marked following plain distilled water application than following application of 5% or 10% dextrose.

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