• William S Dodd, Pascal M Jabbour, Ahmad Sweid, Stavropoula Tjoumakaris, Michael R Gooch, Fadi Al Saiegh, David M Hasan, Robert M Starke, Peter T Kan, Adam J Polifka, Dimitri Laurent, Katharina M Busl, Ritam Ghosh, Brian L Hoh, and Nohra Chalouhi.
• Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
• World Neurosurg. 2021 Sep 1; 153: e259e264e259-e264.

ObjectiveThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is a pressing public health issue. Although most cases do not result in severe illness requiring hospitalization, there is increasing evidence that SARS-CoV-2-induced inflammation can exacerbate pre-existing diseases. We sought to describe the characteristics of patients with aneurysmal subarachnoid hemorrhage who were actively or very recently infected with SARS-CoV-2.MethodsWe reviewed subarachnoid hemorrhage cases of patients who also were positive for SARS-CoV-2 at 5 high-volume cerebrovascular centers in the United States from March 2020 to January 2021. Cases of aneurysmal subarachnoid hemorrhage were analyzed.ResultsA total of 10 patients were identified, consisting of 5 women (50%) and 5 men (50%). Median age was 38.5 years. Four of the 10 patients (40%) were asymptomatic with respect to SARS-CoV-2-related symptoms, 3 patients (30%) had mild-to-moderate symptoms, and 3 patients (30%) had severe coronavirus disease 2019 (COVID-19), with pneumonia and sepsis. Of the 10 cases, 4 had dissecting pseudoaneurysms (40%), 3 in the posterior circulation and 1 in the anterior circulation. Among 6 saccular/blister aneurysms, 4 (67%) were ≤4 mm in largest diameter.ConclusionsOur experience with aneurysmal subarachnoid hemorrhage in patients positive for COVID-19 reveals a possibly distinct pattern compared with traditional aneurysmal subarachnoid hemorrhage, namely a high frequency of small aneurysms, dissecting pseudoaneurysms, and young patients.Copyright © 2021 Elsevier Inc. All rights reserved.

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