• Jin-Feng Wu, Quan-Wei Yin, You-Zhi Pan, Xue Wang, Jian-Ping Qin, Jia-Chun Li, Wen-Zhe Huang, and Zhen-Zhong Wang.
• Nanjing University of Chinese Medicine, Nanjing 210023, China.
• Zhongguo Zhong Yao Za Zhi. 2016 Sep 1; 41 (17): 3244-3251.

AbstractThis study was aimed to qualitatively analyze the chemical components in Congrong Zonggan capsule by using ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry method (UPLC-Q-TOF-MS/MS). An Agilent SB-C₁₈ Rapid Resolution HD (3.0 mm×100 mm,1.8 μm) was used with acetonitrile (A) - 0.1% formic acid solution (B) as the mobile phase for gradient elution. The flow rate was 0.2 mL•min⁻¹; the detection wavelength was set at 330 nm and the column temperature was maintained at 30 ℃. Electrospray ion (ESI) source was applied for the qualitative analysis under the negative ion mode. Finally, based on comparison with standard samples, database matching analysis and reviewing relevant literature, 41 compounds were identified from Congrong Zonggan capsule. This method could be used to rapidly detect the chemical components in Congrong Zonggan capsule, providing reference for the quality control of Congrong Zonggan capsule and laying a foundation for the further study on active components mechanism.Copyright© by the Chinese Pharmaceutical Association.

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