• Turk J Gastroenterol · Dec 2010

    Case Reports

    Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox.

    • Maşallah Baran, Funda Özgenç, Ömer Berk, Demir Gökçe, Kaan Kavakli, Funda Yilmaz, Sait Şen, and Raşit Vural Yağci.
    • Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, İzmir.
    • Turk J Gastroenterol. 2010 Dec 1; 21 (4): 448-51.

    AbstractAutoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.

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