• J. Thromb. Haemost. · Jan 2009

    Randomized Controlled Trial Multicenter Study

    Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial.

    • E Rey, P Garneau, M David, R Gauthier, L Leduc, N Michon, F Morin, C Demers, S R Kahn, L A Magee, and M Rodger.
    • Division of Obstetrics Medicine, Department of Obstetrics and Gynaecology, CHU Sainte-Justine, Montreal, QC, Canada. evelyne_rey@ssss.gouv.qc.ca
    • J. Thromb. Haemost. 2009 Jan 1;7(1):58-64.

    BackgroundThe role of anticoagulants for the prevention of placental-mediated pregnancy complications is uncertain.ObjectivesOur aim was to investigate the effectiveness of dalteparin, a low-molecular-weight heparin, in preventing the recurrence of these complications in women without thrombophilia.Patients/MethodsBetween August 1 2000 and June 20 2007, 116 pregnant women with: (i) ResultsAmong the 110 women included in the final analysis, dalteparin was associated with a lower rate of the primary outcome [5.5% (n = 3/55) vs. 23.6% (n = 13/55), adjusted odds ratio (OR) 0.15, 95% confidence interval (CI) 0.03-0.70]. Secondary outcomes were not statistically different between the groups. Bleeding problems or thrombocytopenia did not occur.ConclusionIn this pilot study, dalteparin is effective in decreasing the recurrence of placental-mediated complications in women without thrombophilia. Our results require confirmation in further randomized trials.

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