• Roberta Costa, Paolo Navalesi, Massimo Antonelli, Franco Cavaliere, Andrea Craba, Rodolfo Proietti, and Giorgio Conti.
• Dipartimento di Anestesia e Rianimazione, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy.
• Chest. 2005 Oct 1;128(4):2984-90.

ObjectiveTo evaluate the effects of various levels of pressure support (PS) during noninvasive ventilation delivered through a helmet on breathing pattern, inspiratory effort, CO2 rebreathing, and comfort.DesignPhysiologic study.SettingUniversity-affiliated hospital.Patients And ParticipantsEight healthy volunteers.InterventionsVolunteers received ventilation through a helmet with four different PS/positive end-expiratory pressure combinations (5/5 cm H2O, 10/5 cm H2O, 15/5 cm H2O, and 10/10 cm H2O) applied in random order.Measurements And ResultsThe ventilatory respiratory rate, esophageal respiratory rate (RRpes), airway pressure, esophageal pressure tracings, esophageal swing, and pressure-time product (PTP) [PTP per breath, PTP per minute, and PTP per liter] were evaluated. We also measured the partial pressure of inspired CO2 (Pi(CO2)) at the airway opening, mean partial pressure of expired CO2 (Pe(CO2)), CO2 production (V(CO2)), minute ventilation (V(E)) delivered to the helmet (V(E)h), and the true inspired V(E). By subtracting V(E) from V(E)h, we obtained the Ve washing the helmet (V(E)wh). A visual analog scale (from 0 to 10) was used to evaluate comfort. Compared to spontaneous breathing, different levels of PS progressively increased tidal volume (V(T)) and decreased RRpes, reducing inspiratory effort. The increased levels of assistance did not produce significant changes in Pi(CO2), end-tidal CO2, and V(CO2). Pe(CO2) had a slight decrease when increasing the level of PS from 5 to 10 cm H2O (p < 0.05). Despite the presence of constant values of Ve, the increase of PS produced an increase in V(E)wh, without significant differences comparing 10 cm H2O and 15 cm H2O of PS. The subjects had a slight but not significant increase in discomfort by augmenting the level of assistance. At the highest level of PS (15 cm H2O), the discomfort was significantly higher (p < 0.001) than at the other levels of assistance.ConclusionIn volunteers, the helmet is efficient in ventilation, allowing a Vt increase and RRpes reduction. A significant discomfort was present only at the highest level of assistance; however, it did not affect patient/ventilator interaction.

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