• Ahmet Uyanıkoğlu, Tevfik Sabuncu, Rukiye Yıldız, Çiğdem Cindioğlu, Adnan Kirmit, and Özcan Erel.
• Department of Gastroenterology, Harran University School of Medicine, Şanlıurfa, Turkey.
• Turk J Gastroenterol. 2019 Oct 1; 30 (10): 899-902.

Background/AimsThe aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).Materials And MethodsA total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.ResultsThe mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.ConclusionWe found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

20 keywords...

hide…