• Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi · Dec 2020

    Review

    [A concise review of telomere and telomerase-related genetic markers in fibrotic lung diseases].

    • Y L Fan and Q Ye.
    • Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
    • Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2020 Dec 20; 38 (12): 952-956.

    AbstractFibrotic lung diseases are a heterogeneous group of diffuse parenchymal lung diseases caused by various factors. Pulmonary fibrosis is one of the common pathological changes of advanced fibrotic lung diseases. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder with unknown etiology. IPF mainly affects the elderly that is considered as an aging related disease. Telomeres are specialized structures at the ends of chromosomes. Telomere shortening results in cellular senescence or apoptosis. Telomerase is a ribonucleoprotein complex that maintains telomere length and genome stability. The telomere shortening and mutations in telomere-related genes are associated with incidence and prognosis of pulmonary fibrosis. Here, a concise review of telomere and telomerase-related genomic markers in IPF and other fibrotic lung diseases is written.

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