• Shradha Agarwal and Paula J Busse.
• Division of Clinical Immunology, Mount Sinai School of Medicine, New York, New York 10029, USA.
• Ann. Allergy Asthma Immunol. 2010 Mar 1; 104 (3): 183-90; quiz 190-2, 210.

ObjectiveTo review the effect of increasing age on the immune system and some of its clinical implications.Data SourcesMEDLINE and PubMed searches were performed cross-referencing the keywords immunosenescence, aging, and immunity. Articles were reviewed for additional citations.Study SelectionArticles were reviewed and selected based on relevance to subject matter.ResultsThe study of immunosenescence is complex and not completely understood. Aging affects both the innate and adaptive arms of the immune response. With increased age, there may be a decrease in phagocytosis, alteration of cellular migration, changes in cell populations and numbers, and a decreased ability to produce specific antibodies. Clinically, these changes potentially increase morbidity and mortality in elderly individuals through an increased rate of infections, malignancy, and autoimmunity.ConclusionsThe process of aging is accompanied by diverse changes in immunity. Several therapeutic approaches are under investigation, including cytokine therapy, hormonal replacement, antioxidant supplementation, and caloric restriction, to attenuate or potentially reverse immunosenescence.

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