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- S M Bonner and A K Pridie.
- Anaesthetics Department, Freeman Hospital, Newcastle upon Tyne, UK.
- Anaesthesia. 1997 Dec 1;52(12):1205-7.
AbstractWe describe the loss of function in the sciatic nerve after an uneventful sciatic nerve block using 25 ml of lignocaine 1% with adrenaline 1 in 200,000 in a patient receiving beta blocker drugs. Lack of pain on injection and complete regeneration of the nerve after 12 months in a patient with severe peripheral vascular disease led us to postulate ischaemic nerve damage as a mechanism of injury. Adrenaline-induced unopposed alpha-mediated vasoconstriction in a beta-blocked patient is suggested as a possible mechanism of peripheral nerve injury worthy of further investigation.
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