• Acta Anaesthesiol Scand · Feb 1990

    The effect on uteroplacental blood flow of epidural anaesthesia containing adrenaline for caesarean section.

    • A Skjöldebrand, J Eklund, N O Lunell, L Nylund, B Sarby, and S Thornström.
    • Department of Anaesthesiology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
    • Acta Anaesthesiol Scand. 1990 Feb 1; 34 (2): 85-9.

    AbstractThe effect on uteroplacental blood flow of an epidural anaesthesia containing adrenaline for caesarean section was investigated in ten healthy women using dynamic placental scintigraphy with indium-113m and a computer-linked gamma camera. The epidural anaesthesia was performed with 18-22 ml bupivacaine 5 mg/ml with adrenaline 2.5 micrograms/ml followed by an i.v. balanced electrolyte infusion of 10 ml/kg b.w. A significant median decrease in the total maternal placental blood flow of 34% was found (P less than 0.01). There was also a significant decrease in maternal mean blood pressure of 3 mmHg (0.4 kPa) (P less than 0.05) and a significant negative correlation between the change in maternal blood pressure and the change in uteroplacental blood flow (r = -0.69, P less than 0.05).

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