• Medicine · Sep 2021

    Meta Analysis

    Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis.

    • Ren-Fei Shan, Yan-An Zhu, Jie Qin, and Jian-Ping Chen.
    • Department of Emergency, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
    • Medicine (Baltimore). 2021 Sep 24; 100 (38): e27151e27151.

    PurposeThis study aimed to assess the efficacy of traditional Chinese medicine (TCM) in septic patients treated with ulinastatin.MethodsPubMed, EmBase, and the Cochrane library were searched up to January 2021 to identify randomized controlled trials. The weight mean difference (WMD) and relative risk (RR) with 95% confidence intervals were used with the random-effects model.ResultsTwenty-three randomized controlled trials with 1903 septic patients were included. TCM significantly reduced the APACHE II score (WMD: -5.18; P < .001), interleukin-6 (WMD: -63.00; P < .001), tumor necrosis factor-α (WMD: -8.86; P < .001), c-reactive protein (WMD: -9.47; P < .001), mechanical ventilation duration (WMD: -3.98; P < .001), intensive care unit stay (WMD: -4.18; P < .001), procalcitonin (WMD: -0.53; P < .001), lipopolysaccharide (WMD: -9.69; P < .001), B-type natriuretic peptide (WMD: -159.87; P < .001), creatine kinase isoenzyme MB (WMD: -45.67; P < .001), cardiac troponin I (WMD: -0.66; P < .001), and all-cause mortality risk (RR: 0.55; P < .001).ConclusionsTCM lowers inflammation levels and reduces the risk of all-cause mortality for septic patients.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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