• Neuroscience · May 2022

    Dendritic branch-constrained NMDA spikes drive synaptic plasticity in hippocampal CA3 pyramidal cells.

    • Federico Brandalise, Stefano Carta, Roberta Leone, Fritjof Helmchen, Anthony Holtmaat, and Urs Gerber.
    • Department of Basic Neurosciences and the Center for Neuroscience, Centre Médical Universitaire (CMU), University of Geneva, 1211 Geneva, Switzerland; Former affiliation(b). Electronic address: federico.brandalise@unige.ch.
    • Neuroscience. 2022 May 1; 489: 57-68.

    AbstractN-methyl-d-aspartate receptor-mediated ( spikes can be causally linked to the induction of synaptic long-term potentiation (LTP) in hippocampal and cortical pyramidal cells. However, it is unclear if they regulate plasticity at a local or global scale in the dendritic tree. Here, we used dendritic patch-clamp recordings and calcium imaging to investigate the integrative properties of single dendrites of hippocampal CA3 cells. We show that local hyperpolarization of a single dendritic segment prevents NMDA spikes, their associated calcium transients, as well as LTP in a branch-specific manner. This result provides direct, causal evidence that the single dendritic branch can operate as a functional unit in regulating CA3 pyramidal cell plasticity.Copyright © 2022 IBRO. Published by Elsevier Ltd.. All rights reserved.

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