• Dement Geriatr Cogn Disord · Jan 2008

    Neural correlates of the Clock Drawing Test performance in Alzheimer's disease: a FDG-PET study.

    • Dong Young Lee, Eun Hyun Seo, Il Han Choo, Shin Gyeom Kim, Jae Sung Lee, Dong Su Lee, Jin Hyeong Jhoo, Ki Woong Kim, Jong Choul Youn, and Jong Inn Woo.
    • Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
    • Dement Geriatr Cogn Disord. 2008 Jan 1;26(4):306-13.

    Background/AimThis study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer's disease (AD).MethodThe CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis.ResultsSignificant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex.ConclusionThese results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex.Copyright 2008 S. Karger AG, Basel.

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