• Byul Hee Yoon, Joonho Byun, Moinay Kim, Seungjoo Lee, Jung Cheol Park, Jae Sung Ahn, and Wonhyoung Park.
• Department of Neurosurgery, Uijeongbu Eulji Medical Center, Uijeongbu city, Gyeonggi-do, Korea.
• World Neurosurg. 2022 Feb 1; 158: e128-e137.

BackgroundCardiac myxoma is a very rare disease for which resection is the gold standard treatment. Many neurological manifestations are associated with this disease, including embolic infarctions, arterial aneurysms, and brain metastatic myxomas, but few large-scale studies have addressed this. The aim of this study was to retrospectively analyze the incidence, type, and prognosis of these neurological disorders.MethodsWe enrolled 317 patients who underwent a cardiac myxoma resection between 2004 and 2019 at our institution. A retrospective review of medical records and radiological imaging was performed for each patient, and clinical factors were compared and analyzed with regard to clinical outcomes and the incidence of adverse events.ResultsPatients with a neurological disorder before surgery were found to be more likely to develop new postoperative neurological complications (P = 0.003). Patients with a neurological disorder arising at any time before or after surgery had poorer outcomes (P < 0.001).ConclusionsThe clinical management of cardiac myxoma must take account of neurological sequelae independently of the surgical intervention to remove the lesion. Patients with cardiac myxoma and any neurological disorder should undergo both neurosurgical follow-up and cardiac surgical follow-up, even if myxoma removal surgery has been performed. We recommend active neuroimaging during long-term follow-up as essential in these cases.Copyright © 2021 Elsevier Inc. All rights reserved.

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