• Neuroscience · Jan 2022

    Sleep quality modulates the association between dynamic functional network connectivity and cognitive function in healthy older adults.

    • Hong-Zhou Xu, Xue-Rui Peng, Yun-Rui Liu, Xu Lei, and Jing Yu.
    • Faculty of Psychology, Southwest University, Chongqing, China.
    • Neuroscience. 2022 Jan 1; 480: 131-142.

    AbstractAging is associated with changes in sleep, brain activity, and cognitive function, as well as the association among these factors; however, the precise nature of these changes has not been elucidated. This study systematically investigated the modulatory effect of sleep on the relationship between brain functional network connectivity (FNC) and cognitive function in older adults. In total, 107 community-dwelling healthy older adults were recruited and assigned into poor sleep and good sleep groups based on the Pittsburgh Sleep Quality Index. The static functional network connectivity (sFNC), the temporal variability of dynamic FNC (dFNC) from variance (dFNC-var), and the dFNC from clustering state (dFNC-state) were calculated. Corresponding cognition-predictive models were constructed for each sleep group. dFNC but not sFNC, was able to significantly predict the cognitive function in older adults. Specifically, sleep played a modulatory role in the association between dFNC and cognitive function, with sleep-specific variations at both microscopic (i.e., specific edges) and macroscopic levels (i.e., specific states) of dFNC.Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…