• Neuroscience · May 2022

    GABAergic Interneurons with nonlinear dendrites: from neuronal computations to memory engrams.

    • Alexandra Tzilivaki, George Kastellakis, Dietmar Schmitz, and Panayiota Poirazi.
    • Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany; Einstein Center for Neurosciences Berlin, Charitéplatz 1, 10117 Berlin, Germany; Neurocure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany; Foundation for Research and Technology Hellas, Institute of Molecular Biology and Biotechnology, Greece.
    • Neuroscience. 2022 May 1; 489: 34-43.

    AbstractGABAergic interneurons (INs) are a highly diverse class of neurons in the mammalian brain with a critical role in orchestrating multiple cognitive functions and maintaining the balance of excitation/inhibition across neuronal circuitries. In this perspective, we discuss recent findings regarding the ability of some IN subtypes to integrate incoming inputs in nonlinear ways within their dendritic branches. These recently discovered features may endow the specific INs with advanced computing capabilities, whose breadth and functional contributions remain an open question. Along these lines, we discuss theoretical and experimental evidence regarding the potential role of nonlinear IN dendrites in advancing single neuron computations and contributing to memory formation.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

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