• Anesthesiology · Jan 2003

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery.

    • Rolf Rossaint, Matthias Reyle-Hahn, Jochen Schulte Am Esch, Jens Scholz, Philippe Scherpereel, Benoit Vallet, Francesco Giunta, Monica Del Turco, Wilhelm Erdmann, Rob Tenbrinck, Alfons F Hammerle, Peter Nagele, and Xenon Study Group.
    • Department of Anesthesiology of the University Hospital, RWTH Aachen, Germany. rossaint@post.rwth-aachen.de
    • Anesthesiology. 2003 Jan 1;98(1):6-13.

    BackgroundAll general anesthetics used are known to have a negative inotropic side effect. Since xenon does not have a negative inotropic effect, it could be an interesting future general anesthetic. The aim of this clinical multicenter trial was to test the hypothesis of whether recovery after xenon anesthesia is faster compared with an accepted, standardized anesthetic regimen and that it is as effective and safe.MethodA total of 224 patients in six centers were included in the protocol. They were randomly assigned to receive either xenon (60 +/- 5%) in oxygen or isoflurane (end-tidal concentration, 0.5%) combined with nitrous oxide (60 +/- 5%). Sufentanil (10 mcirog) was intravenously injected if indicated by defined criteria. Hemodynamic, respiratory, and recovery parameters, the amount of sufentanil, and side effects were assessed.ResultsThe recovery parameters demonstrated a statistically significant faster recovery from xenon anesthesia when compared with isoflurane-nitrous oxide. The additional amount of sufentanil did not differ between both anesthesia regimens. Hemodynamics and respiratory parameters remained stable throughout administration of both anesthesia regimens, with advantages for the xenon group. Side effects occurred to the same extent with xenon in oxygen and isoflurane-nitrous oxide.ConclusionThis first randomized controlled multicenter trial on the use of xenon as an inhalational anesthetic confirms, in a large group of patients, that xenon in oxygen provides effective and safe anesthesia, with the advantage of a more rapid recovery when compared with anesthesia using isoflurane-nitrous oxide.

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