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Neuroimaging Clin. N. Am. · Aug 2005
ReviewExtending the time window for thrombolysis: evidence from acute stroke trials.
- Howard A Rowley.
- Department of Radiology, University of Wisconsin, Madison, WI 53792, USA. ha.rowley@hosp.wisc.edu
- Neuroimaging Clin. N. Am. 2005 Aug 1; 15 (3): 575-87, x.
AbstractData from intravenous tissue plasminogen activator studies have shown rapidly diminishing clinical benefit beyond 3 hours when noncontrast CT is used for treatment triage. Newer trials, such as the Desmoteplase in Acute Ischemic Stroke trial, have now successfully pushed the time window out to 9 hours using the concept of penumbral imaging and treatment of the perfusion-diffusion mismatch. Advanced imaging with CT or MR imaging protocols is providing a means for rational physiologic selection and outcomes assessment in stroke treatment.
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