• Neuromodulation · Jun 2022

    Randomized Controlled Trial

    Effectiveness of Repetitive Transcranial Magnetic Stimulation on Fibromyalgia Patients Responding to a First Repetitive Transcranial Magnetic Stimulation Induction Course After Six Months of Maintenance Treatment: A Randomized Pilot-Controlled Study.

    • Aurélie Lacroix, Pascale Vergne-Salle, Jean-Christophe Dumont, Anaïs Labrunie, Patrice Balestrat, Benjamin Calvet, and Murielle Girard.
    • Unité de Recherche et d'Innovation, Centre Hospitalier Esquirol, Limoges, France; Inserm U1094, IRD U270, Université Limoges, CHU Limoges, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d'Epidémiologie et de Neurologie Tropicale, OmegaHealth, Limoges, France. Electronic address: Aurelie.LACROIX@ch-esquirol-limoges.fr.
    • Neuromodulation. 2022 Jun 1; 25 (4): 624-632.

    BackgroundFibromyalgia is a chronic painful condition without real, effective treatment. The administration of repetitive transcranial magnetic stimulation (rTMS) has been shown to have a therapeutic effect on pain, but there are still questions about the maintenance of its effect over time. Continuation of the treatment upon clinical response through maintenance sessions is promising and merits further exploration.Materials And MethodsWe conducted a randomized, parallel-group, controlled study involving 78 patients to evaluate the effect of rTMS vs sham stimulation after a three-week induction treatment and six months of maintenance treatment (three-week periodicity) on 22 patients who presented a clinical response to the induction treatment. The clinical response was defined as a ≥30% decrease of the baseline visual analog scale (VAS) for pain and a score for the Patient Global Impression of Change (PGIC) >5. The clinic global impression, fibromyalgia impact questionnaire, symptom severity score, and Beck's depression inventory were also studied.ResultsA significant clinical response to treatment with rTMS was observed after the induction phase and maintained over six months, particularly as measured by the PGIC parameter of pain, as well as of the intensity of fatigue and depression, with an absence of adverse effects induced by this method.ConclusionA three-week rTMS treatment, characterized by a reduction in pain, as evaluated by VAS, should be continued with the administration of rTMS maintenance sessions for an additional six months to maintain the best possible long-term effects.Copyright © 2022 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

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