• Feng Liao, Zongdong Zhu, Chengwei Xiao, Bo Tan, Xiaoming Tang, Dan Wei, Jiabin Yuan, Xuemei Xiang, and Jiang Hu.
• Department of Orthopaedics, Affiliated Hospital of University of Electronic Science and Technology & Sichuan Provincial People's Hospital.
• Medicine (Baltimore). 2020 Apr 1; 99 (14): e19684.

BackgroundFracture is a common disease; many factors affect fracture healing. Recent studies have confirmed that hydrogen sulfide (H2S) plays an essential role in bone formation, but most of these studies are drawing conclusions based on animal experiment; whether H2S could promote fracture healing in patients is still unclear. We aim to investigate the change of serum H2S in fracture patients, and analyze its effort on fracture healing.MethodsThis is a single-center, prospective cohort study. Patients with spinal or limb fracture will be recruited. Patient's serum and urine will be collected at baseline for examination (serum H2S, β-CTX, OC, PINP, 25-OH-VitD3, S-CTX, urinary calcium, and urinary creatinine). All patients will be followed-up for 24 months in outpatients settings, the image of X-ray or CT will be reviewed and fracture healing will be judged by 2 experienced orthopedic physicians. The difference in serum parameters especially H2S will be compared between patients with fracture healed within 9 months and those with fracture unhealed at 9 months.DiscussionResults of the trial could provide insight into influence of H2S on fracture healing.Ethics And DisseminationThe study was approved by the ethics committee of School of Medicine UESTC & Sichuan Provincial People's Hospital Ethics Committee. All the participants will be asked to provide written informed consent before data collection. The findings of the study will be published in peer-reviewed journals and will be presented at national or international conferences.

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