• World Neurosurg · May 2022

    Randomized Controlled Trial

    Case-Control Study Design in Neurological Surgery.

    • Kimberly P Kicielinski.
    • Department of Neurological Surgery, Medical University of South Carolina, Charleston, South Carolina, USA. Electronic address: kicielin@musc.edu.
    • World Neurosurg. 2022 May 1; 161: 275-279.

    AbstractThe hallmark of case-control study design involves dividing groups based on outcome and looking back at exposures to determine associations. Case-control studies are ideal for scenarios when outcomes are rare, making them well suited to the infrequent events often found among neurosurgical diseases. It is also a favorable design for scenarios when it would be infeasible or unethical to assign treatment groups as is necessary for a randomized controlled trial. Case-control studies are powerful but often misapplied and mislabeled. This article provides an overview of case-control study design along with discussion of a real-world example of an effectively executed case-control study.Copyright © 2022 Elsevier Inc. All rights reserved.

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