• Akihiko Hiyama, Daisuke Sakai, Hiroyuki Katoh, Masato Sato, and Masahiko Watanabe.
• Department of Orthopaedic Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan. Electronic address: a.hiyama@tokai-u.jp.
• World Neurosurg. 2022 Aug 1; 164: e706-e717.

Study DesignThis was a retrospective observational study.ObjectivesThe purpose of this study was to evaluate bone mineral density using Hounsfield unit (HU) values at the upper instrumented vertebrae (UIV), UIV+1, and UIV+2 and to investigate the association with proximal junctional failure (PJF) in female patients with adult spinal deformity (ASD). We also evaluated the relationship between the global alignment and proportion (GAP) score and the HU value of patients after ASD surgery.MethodsFifty-two patients (52 females, mean age =70.2 years) who underwent multiple-level lateral lumbar interbody fusion combined with posterior instrumentation for ASD were included. The patients were divided into 2 groups, PJF and non-PJF. The demographics, surgical characteristics, and radiographic parameters were compared. Vertebral HU values at UIV, UIV+1, and UIV+2 using preoperative computed tomography scans and immediate postoperative GAP scores were also compared.ResultsPJF was found in 13 of 52 patients (25.0%). Preoperative and postoperative thoracic kyphosis was large in PJF patients. Based on the total GAP score, there was no significant difference among the categories of GAP scores (P = 0.514). The statistically significant difference in mean HU values (116.6 ± 28.1 vs. 141.8 ± 41.8, P = 0.049) between the two groups at UIV. Further correlation analysis showed that the mean HU values in UIV and UIV+1 showed a significantly negative correlation coefficient with the total GAP score.ConclusionsOur study suggests that preoperative HU values at UIV may affect the development of PJF for female ASD patients. HU evaluation by preoperative computed tomography may help reduce the incidence of PJF.Copyright © 2022 Elsevier Inc. All rights reserved.

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