• Vera Crone, MøllerMorten HylanderMHDepartment of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.Collaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark., Anders Perner, Waleed Alhazzani, and Mette Krag.
• Department of Intensive Care, Holbaek Hospital, Holbaek, Denmark.
• Acta Anaesthesiol Scand. 2022 Sep 1; 66 (8): 102410261024-1026.

BackgroundGastrointestinal motility is an important contributor to the effective uptake of water and nutrition. However, it is often impaired in acutely ill hospitalised patients. Amongst other indications, prokinetic agents are used to improve GI motility, but the body of evidence is not well described. Accordingly, we aim to systematically describe and explore the body of evidence on the use of prokinetic agents in hospitalised adults.MethodsIn accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews statement, we plan to conduct a scoping review of studies assessing the use of prokinetic agents, for any indication, in hospitalised adults. We plan to assess study design, population, agents, indications and outcomes across included studies. When applicable, we plan to assess the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.ResultsWe plan to provide descriptive analyses of the included studies accompanied by tabulated results and characterise knowledge gaps.ConclusionThe outlined scoping review will provide a summary of the body of evidence on the use, indications, effects and side effects of prokinetic agents in hospitalised adults.© 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

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