• Guang-Yao Lin, Yan Liu, Tao Ye, Xin-Yu Lu, Jie Gao, and Yong-Zhou Wang.
• Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32568e32568.

RationaleGranular cell tumor (GCT) of the vulva is an exceptionally rare female genital tract tumor. The majority of these are benign and there are no standardized surgical techniques for the special site to reduce tension of the wound.Patient ConcernsA 47-years-old Chinese woman experienced a nodule on her right vulva with itch sometimes in late 2018.DiagnosesMagnetic resonance imaging showed a high possibility of vulvar cancer. While Chest X-ray, abdominal sonography, and cystoscopy examination were unremarkable.InterventionsThe patient underwent local complete resection of vulvar tumor under general anesthesia on March 24, 2022. The resection scope was approximately 4 cm × 3 cm × 3 cm. Due to the large surgical incision, Z-plasty was performed to achieve the primary closure for decreasing wound tension and improving aesthetic reduction.OutcomesThe final pathological diagnosis was benign GCT of the vulva and surgical margins were uninvolved. At 8 months follow-up, no new lesions were detected.LessonsSurgery with negative resection margins is the mainstay for benign GCT of the vulva, while Z-plasty is appropriate for decreasing the tension of the wound and improving aesthetic reduction.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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