• J Coll Physicians Surg Pak · Dec 2022

    Case Reports

    Thymic Seminoma with Regressive Changes Obscured by Granulomatous Reaction.

    • Ayse Nur Akatli, Emine Samdanci, Muhammet Reha Celik, Saadet Alan, Hakki Ulutas, and Nusret Akpolat.
    • Department of Pathology, School of Medicine, Inonu University, Malatya, Turkey.
    • J Coll Physicians Surg Pak. 2022 Dec 1; 32 (12): SS197SS199SS197-SS199.

    AbstractPrimary thymic seminoma is an exceedingly rare tumour. There are few case reports about mediastinal thymic seminoma accompanied by secondary changes. We report a case of a 29-year male admitted to our hospital because of chest pain and dyspnea for 8 months. Computed tomography of the thorax revealed hypodense, solid masses showing calcification and cystic degeneration in the anterior mediastinum. Histopathological examination of the resected specimen revealed a diagnosis of thymic seminoma with regressive and reactive changes. The present case was unique in its presentation as a primary seminoma showing combination of cystic degeneration, follicular hyperplasia, fibrosis, calcification and granulomatous reaction in one case. High level of suspicion is necessary to identify seminomas in a thymic lesion accompanied by secondary changes. Excluding the possibility of metastasis from testicular seminoma is very important before making this diagnosis. Key Words: Thymus, Seminoma, Granuloma, Calcification, Cyst.

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