• Annals of surgery · Oct 2023

    Randomized Controlled Trial

    Locoregional Failure During and After Short-course Radiotherapy followed by Chemotherapy and Surgery Compared to Long-course Chemoradiotherapy and Surgery - A Five-year Follow-up of the RAPIDO Trial.

    • Esmée A Dijkstra, Per J Nilsson, HospersGeke A PGAP0000-0002-3047-7892Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Renu R Bahadoer, Elma Meershoek-Klein Kranenbarg, Annet G H Roodvoets, Hein Putter, Åke Berglund, Andrés Cervantes, CrollaRogier M P HRMPH0000-0003-2617-1791Department of Surgery, Amphia Hospital, Breda, The Netherlands., Mathijs P Hendriks, Jaume Capdevila, Ibrahim Edhemovic, MarijnenCorrie A MCAM0000-0003-0189-5953Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands., van de VeldeCornelis J HCJH0000-0003-0104-1800Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Bengt Glimelius, Boudewijn van Etten, and Collaborative Investigators.
    • Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    • Ann. Surg. 2023 Oct 1; 278 (4): e766e772e766-e772.

    ObjectiveTo analyze risk and patterns of locoregional failure (LRF) in patients of the RAPIDO trial at 5 years.BackgroundMultimodality treatment improves local control in rectal cancer. Total neoadjuvant treatment (TNT) aims to improve systemic control while local control is maintained. At 3 years, LRF rate was comparable between TNT and chemoradiotherapy in the RAPIDO trial.MethodsA total of 920 patients were randomized between an experimental (EXP, short-course radiotherapy, chemotherapy, and surgery) and a standard-care group (STD, chemoradiotherapy, surgery, and optional postoperative chemotherapy). LRFs, including early LRF (no resection except for organ preservation/R2 resection) and locoregional recurrence (LRR) after an R0/R1 resection, were analyzed.ResultsTotally, 460 EXP and 446 STD patients were eligible. At 5.6 years (median follow-up), LRF was detected in 54/460 (12%) and 36/446 (8%) patients in the EXP and STD groups, respectively ( P =0.07), in which EXP patients were more often treated with 3-dimensional-conformed radiotherapy ( P =0.029). In the EXP group, LRR was detected more often [44/431 (10%) vs. 26/428 (6%); P =0.027], with more often a breached mesorectum (9/44 (21%) vs. 1/26 (4); P =0.048). The EXP treatment, enlarged lateral lymph nodes, positive circumferential resection margin, tumor deposits, and node positivity at pathology were the significant predictors for developing LRR. Location of the LRRs was similar between groups. Overall survival after LRF was comparable [hazard ratio: 0.76 (95% CI, 0.46-1.26); P =0.29].ConclusionsThe EXP treatment was associated with an increased risk of LRR, whereas the reduction in disease-related treatment failure and distant metastases remained after 5 years. Further refinement of the TNT in rectal cancer is mandated.Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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