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- Erin T Wong, Anish Kapadia, Venkatagiri Krishnamurthy, and David J Mikulis.
- Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; Department of Medical Imaging, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
- Neuroimaging Clin. N. Am. 2023 May 1; 33 (2): 335342335-342.
AbstractCerebrovascular reactivity (CVR) reflects the change in cerebral blood flow in response to vasodilatory stimuli enabling assessment of the health of the cerebral vasculature. Recent advances in the quantitative delivery of CO2 stimuli with computer-controlled sequential gas delivery have enabled mapping of the speed and magnitude of response to flow stimuli. These CVR advances when applied to patients with acute concussion have unexpectedly shown faster speed and greater magnitude of responses unseen in other diseases that typically show the opposite effects. The strength of the CVR alterations have diagnostic potential in single subjects with AUC values in the 0.90-0.94 range.Copyright © 2023 Elsevier Inc. All rights reserved.
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