• J Trauma · Jul 2004

    Comparative Study

    Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.

    • Raymond J Connolly.
    • Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA. rconnolly@tufts-nemc.org
    • J Trauma. 2004 Jul 1;57(1 Suppl):S26-8.

    BackgroundThe Rapid Deployment Hemostat (RDH) Bandage was developed for the rapid control of bleeding caused by trauma.MethodsAn extremity wound involving skin, muscle, bone, and femoral arterial injury and a 1-cm vertical incision in the abdominal aorta in swine were studied to compare the RDH Bandage, a fibrin sealant dressing and gauze to restore hemostasis. The total blood loss was determined and the survival of animals was measured.ResultsIn the extremity injury model, the RDH Bandage reduced blood loss by 63% compared with the gauze control. In the aorta arterial incision model, the RDH Bandage required a significantly lower compression time to control bleeding compared with gauze and TachoComb. The RDH Bandage was able to stop bleeding from this injury in 100% of the tests.ConclusionThe RDH Bandage was superior to a commercially available fibrin bandage in controlling hemorrhage, decreasing blood loss, and increasing survival.

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