• Jose Alberto Martínez-Hortelano, Carlos Berlanga-Macías, Diana Patricia Pozuelo-Carrascosa, Gema Sanabria-Martínez, Raquel Poyatos-León, and Vicente Martínez-Vizcaíno.
• Universidad de Castilla- La Mancha, Health and Social Care Research Center.
• Medicine (Baltimore). 2019 May 1; 98 (20): e15470e15470.

BackgroundGrowing evidence suggests that interpregnancy weight change (IPWC) is a risk factor for perinatal outcomes, since it may increase the probability of gestational complications including gestational diabetes or cesarean delivery. Additionally, IPWC may affect neonatal outcomes increasing the prevalence of newborns small for gestational age or preterm birth. However, the association between IPWC and perinatal outcomes has not systematically synthesized thus far. This study protocol aims to provide a clear, transparent and standardized procedure for systematically reviewing the association between IPWC and perinatal outcomes.Methods And AnalysisThis systematic review and meta-analyses protocol is based on the preferred reporting items for systematic review and meta-analysis protocols and the Cochrane Collaboration Handbook. MEDLINE, EMBASE, the Cochrane Library, and Web of Science will be systematically searched from their inception. No limits will be defined by study design, as such different tools to assess risk of bias will be used:Odd ratios and their corresponding 95% confidence intervals will be reported to evaluate associations between IPWC and perinatal outcomes.ResultsThe results of this study will be published in a peer-reviewed journal.ConclusionThis systematic review and meta-analysis will systematically synthesize the evidence regarding the association between IPWC and perinatal outcomes. Data will be extracted from published articles and findings will be published in peer-reviewed journals. Ethical approval and informed consent will not be required due to the nature of the study.Systematic Review RegistrationPROSPERO CRD42018100449.

28 keywords...

hide…