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Case Reports
Acute treatment of intracranial hemorrhage complicated by hemophilia a and emicizumab therapy.
- Kacie Clark, Brett M Patrick, and Sterling C Torian.
- Department of Pharmacy, Methodist University Hospital, 1265 Union Avenue, Memphis, TN 38104, USA.
- Am J Emerg Med. 2024 Feb 1; 76: 272.e1272.e2272.e1-272.e2.
AbstractAmong patients with hemophilia A with or without FVIII inhibitors, emicizumab prophylaxis has demonstrated significantly reduced bleeding events. However, emicizumab interferes with clotting-based assays used for monitoring FVIII activity, resulting in falsely elevated FVIII activity. This lack of accurate monitoring can complicate the dosing of intravenous therapeutic FVIII clotting factor concentrates in the treatment of critical bleeding events. This case report aims to inform providers who frequently treat hemophilia-associated hemorrhages about emicizumab's effect on clotting-based assays essential for monitoring factor replacement.Copyright © 2023. Published by Elsevier Inc.
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