• Khalid S Alshaalan, Rahaf F Alkahtani, Renad F Althobaiti, Rana A Aldhahi, Fatimah Z Rebh, Sarah S Algezlan, Salma M Alanazi, Shawg S Alrumaih, Basma A Alturki, Abdullah S Alahmadi, Raneem A Alanazi, Alaa H Al Ali, and Othman M Alshabanah.
• From the Department of Dermatology (Alshaalan); from the Department of Family Medicine (Alahmadi); from the Department of Internal Medicine and Adult Infectious Diseases (Rebh); from the Department of of Intensive Care Unit (Alshabanah), Prince Mohammad Bin Abdul-Aziz Hospital, from the College of Medicine (Alkahtani, Althobaiti, Aldhahi, Algezlan, M. Alanazi, Alrumaih, Alturki, A. Alanazi), Al Imam Muhammad Ibn Saud Islamic University, and from the Department of Internal Medicine and Infectious Diseases (Al Ali), King Saud Medical City, Riyadh, Kingdom of Saudi Arabia.
• Saudi Med J. 2024 Feb 1; 45 (2): 171178171-178.

ObjectivesTo investigate the relationship between statin use and coronavirus disease-19 (COVID-19) severity.MethodsThis was a retrospective study of adult patients with confirmed COVID-19 who were hospitalized at Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia. The study was carried out from July - September 2020. Antecedent statin use was evaluated using medication information available in the electronic medical records.ResultsIn this retrospective study, we collected data from 689 patients hospitalized with COVID-19. Among the patients, 56.2% of them were non-Saudi and 67.3% were males. The mean age of the patients was 53.7 years. The most common comorbidities among patients with COVID-19 at admission were hypertension (65.2%) and diabetes mellitus (65%). Among these patients, 155 (22.5%) patients received statins during hospitalization and 79.7% of them received corticosteroids. Receiving statins significantly increased the risk of intensive care unit's admission by 1.64 times, intubation by 1.76 times, developing complications by 2.48 times, and mortality by 3.16 times.ConclusionStatins are associated with a higher risk of mortality and morbidity among patients hospitalized for COVID-19.Copyright: © Saudi Medical Journal.

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