• Nutrition · May 2024

    Sarcopenia augments the risk of excess weight on COVID-19 hospitalization: A prospective study using the Lifelines COVID-19 cohort.

    • Yinjie Zhu, Jochen O Mierau, BakkerStephan J LSJLDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, The Netherlands., Louise H Dekker, Gerjan J Navis, and Lifelines Corona Research Initiative.
    • Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, The Netherlands. Electronic address: y.zhu@umcg.nl.
    • Nutrition. 2024 May 1; 121: 112361112361.

    ObjectiveWe investigated the associations of sarcopenia alone, overweight or obesity, and sarcopenic overweight or obesity with COVID-19 hospitalization.MethodsParticipants from the Lifelines COVID-19 cohort who were infected with COVID-19 were included in this study. Sarcopenia was defined as a relative deviation of muscle mass of ≤ -1.0 SD from the sex-specific mean 24-h urinary creatinine excretion. Overweight or obesity was defined as a body mass index ≥ 25 kg/m2. Sarcopenic overweight or obesity was defined as the presence of overweight or obesity and low muscle mass. COVID-19 hospitalization was self-reported. Logistic regression models were used to analyze the associations of sarcopenia alone, overweight or obesity, and sarcopenic overweight or obesity with COVID-19 hospitalization.ResultsOf the 3594 participants infected with COVID-19 and recruited in this study, 173 had been admitted to the hospital. Compared with the reference group, individuals with overweight or obesity and sarcopenic overweight or obesity were 1.78-times and 2.09-times more likely to have been hospitalized for COVID-19, respectively, whereas sarcopenia alone did not increase the risk of COVID-19 hospitalization.ConclusionsIn this middle-aged population, sarcopenic overweight or obesity elevated the risk of hospitalization for COVID-19 in those infected with COVID-19 more than overweight or obesity alone. These data support the relevance of sarcopenic overweight or obesity as a risk factor beyond the geriatric setting and should be considered in risk stratification in future public health and vaccination campaigns.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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