• Nutrition · May 2024

    Intermittent fasting associated with coconut oil (Cocos nucifera L.) alters gut-liver axis parameters in diet-induced obese rats.

    • Danielle Melo de Souza, Hassler Clementino Cavalcante, Marcos Dos Santos Lima, Adriano Francisco Alves, Maria Letícia da Veiga Dutra, Aline Barbosa D'Oliveira, Alana Natalícia Vasconcelos de Araújo, Larissa Maria Gomes Dutra, Kamila Sabino Batista, and de Souza AquinoJailaneJLaboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program .
    • Laboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraíba, João Pessoa, Brazil; Postgraduate Program in Nutrition Sciences, Federal University of Paraíba, João Pessoa, Brazil.
    • Nutrition. 2024 May 1; 121: 112370112370.

    ObjectiveThe aim of this article is to investigate the effect of intermittent fasting, associated or not with coconut oil intake, on the gut-liver axis of obese rats.MethodsA total of 50 rats were divided into five groups: control, obese, obese with intermittent fasting, obese with intermittent fasting plus coconut oil, and obese with caloric restriction. The rats were induced to obesity with a high-sugar diet for 17 wk. The respective interventions were carried out in the last 4 wk.ResultsThe groups with intermittent fasting protocols had reduced total cholesterol (on average 54.31%), low-density lipoprotein (on average 53.39%), and triacylglycerols (on average 23.94%) versus the obese group; and the obese with intermittent fasting plus coconut oil group had the highest high-density lipoprotein compared with all groups. The obese with intermittent fasting plus coconut oil and obese with caloric restriction groups had lower metabolic load compared with the other groups. The obese group had high citric and succinic acid concentrations, which affected the hepatic tricarboxylic acid cycle, while all the interventions had reduced concentrations of these acids. No histologic changes were observed in the intestine or liver of the groups.ConclusionIntermittent fasting, especially when associated with coconut oil, had effects comparable with caloric restriction in modulating the parameters of the gut-liver axis.Copyright © 2024 Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…