• Rongchong Huang, Xiantao Song, Haishan Zhang, Wen Tian, Zheng Huang, Xingwei Zhang, Junqing Yang, Dongfeng Zhang, Jian Wu, Lei Zhong, Henry H Ting, and SOS-COMEDY investigators.
• The Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian City The Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing City The Department of Cardiology, First Affiliated Hospital of China Medical University, Shenyang City The Department of Cardiology, Southern Hospital, Southern Medical University, Guangzhou City The Department of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou City The Department of Cardiology, Guangdong General Hospital, Guangzhou City, China Division of Cardiology, Mayo Clinic, Jacksonville, FL.
• Medicine (Baltimore). 2018 Apr 1; 97 (16): e0443e0443.

AimsSuccess of opening single (SOS)-comedy is a prospective multicenter study to compare the improvement in the decrease of myocardial viability by percutaneous coronary intervention (PCI) with that by optimal medical therapy (OMT) alone in patients with chronic total occlusion (CTO) of a single coronary artery.Methods And ResultsThe risks and the benefits of both options (PCI and OMT) were listed in a CTO decision aid (DA). Eligible participants detected by invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) were divided into PCI or OMT groups according to patients' choice after shared-decision making process with DA. Participants will undergo positron emission tomography/computed tomography (PET/CT), cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE), and proceed to ICA and revascularization if possible. Blinded core laboratory interpretation will be performed for ICA, CCTA, PET/CT, CMR, and TTE. All participants will be followed up for 12 months. The primary endpoint is the improvement to the decrease of myocardial viability from baseline assessed with the use of PET/CT after 12-month follow-up.ConclusionsAll of the patients are appropriately consented before enrolling in this study, which has been approved by the Ethics Committee. Results of SOS-COMEDY will be helpful to develop a strategy for single CTO patients.

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