• Ji Min Lee, Kang-Moon Lee, Joo Sung Kim, You Sun Kim, Jae Hee Cheon, Byong Duk Ye, Young-Ho Kim, Dong Soo Han, Chang Kyun Lee, and Hyun-Ju Park.
• Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggi-do Department of Internal Medicine, Seoul National University Department of Internal Medicine, Inje University, Seoul Paik Hospital Department of Internal Medicine, Yonsei University College of Medicine Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul Department of Internal Medicine, Hanyang University Guri Hospital, Gyeonggi-do Department of Internal Medicine, Kyung Hee University Department of Internal Medicine, Daehang Hospital, Seoul, Korea.
• Medicine (Baltimore). 2018 Apr 1; 97 (16): e0459e0459.

AbstractPrevious studies have demonstrated that early surgery in Crohn disease (CD) can result in a better clinical course than late surgery. The aim of this study was to compare the clinical course of CD following bowel resection performed at the time of diagnosis (early surgery) and during the course of the disease (late surgery).We reviewed medical records from a hospital-based cohort database that includes Korean CD patients diagnosed before 2009. Patients who underwent bowel resection were included. Age, sex, disease phenotype, time of surgery, medication history including use of corticosteroids, immunomodulators, and biologics, and further surgical history were assessed.In all, 243 CD patients who had undergone bowel resection were included, and 120 patients underwent surgery at the time of diagnosis, while 123 underwent surgery after diagnosis (median 105 months, range 2-277). The use of biologics was significantly higher in the late surgery group than in the early surgery group (P = .020). The use of immunomodulators and reoperation rates did not differ between the groups. Early surgery was associated with less use of biologics (Kaplan-Meier curve analysis P = .015). Multivariate analysis indicated that early surgery and old age at surgery were independent variables associated with less use of biologics.CD patients who underwent bowel resection at the time of diagnosis have a more favorable disease course, represented by less use of biologics. Early surgery might be a treatment option in a subset of CD patients.

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