• J Neurosurg Anesthesiol · Apr 2024

    Dynamic Cortical Connectivity During Propofol Sedation in Glioma Patients.

    • Wanning Yang, Minyu Jian, Xinxin Wang, Yang Zhou, Yi Liang, Yiwei Chen, Yang Li, Ke Li, Bo Ma, Haiyang Liu, and Ruquan Han.
    • Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
    • J Neurosurg Anesthesiol. 2024 Apr 5.

    BackgroundThe behavioral manifestations and neurophysiological responses to sedation can assist in understanding brain function after neurological damage, and can be described by cortical functional connectivity. Glioma patients may experience neurological deficits that are not clinically detectable before sedation. We hypothesized that patients with gliomas exhibit distinct cortical connectivity patterns compared to non-neurosurgical patients during sedation.MethodsThis is a secondary analysis of a previously published prospective observational study. Patients scheduled for resection of supratentorial glioma (n=21) or a non-neurosurgical procedure (n=21) under general anesthesia were included in this study. Frontal electroencephalography (EEG) signals were recorded at different sedation levels as assessed by the Observer Assessment of Alertness/Sedation (OAA/S) score. Kernel principal component analysis and k-means clustering were used to determine possible temporal dynamics from the weighted phase lag index characteristics.ResultsTen EEG connectivity states were identified by clustering (76% consistency), each with unique properties. At OAA/S 3, the median (Q1, Q3) occurrence rates of state 6 (glioma group, 0.110 [0.083, 0.155] vs. control group, 0.070 [0.030, 0.110]; P=0.008) and state 7 (glioma group, 0.105 [0.083, 0.148] vs. control group: 0.065 [0.038, 0.090]; P=0.001), which are dominated by beta connectivity, were significantly different between the 2 groups, reflecting differential conversion of the beta band between the left and right brain regions. In addition, the temporal dynamics of the brain's functional connectivity was also reflected in the transition relationships between metastable states.ConclusionsThere were differences in EEG functional connectivity, which is dynamic, between the glioma and nonglioma groups during sedation.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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