• Clinics · Jan 2024

    Correlation of serum Klotho, fetuin-A, and MGP levels with coronary artery calcification in maintenance hemodialysis patients.

    • Dan Wang, XiuLin Chu, JuHua Cao, and YunHua Peng.
    • Department of East Hospital Nephrology, Yantaishan Hospital, Yantai City, Shandong Province, China.
    • Clinics (Sao Paulo). 2024 Jan 1; 79: 100417100417.

    ObjectiveThis study was to investigate the role of serum Klotho, fetuin-A, and Matrix Gla Protein (MGP) in Coronary Artery Calcification (CAC) in patients with Maintenance Hemodialysis (MHD) and their predictive value for CAC.Methods100 patients receiving MHD were selected. Serum Klotho, fetuin-A, and MGP levels were detected by ELISA. CAC scores were assessed by coronary CT scan. Multifactor analysis was used to evaluate the risk factors affecting CAC. The ability of serum Klotho, fetuin-A, and MGP levels to diagnose CAC was evaluated by receiver operating characteristic curves.ResultsSerum Klotho, fetuin-A, and MGP were independent risk factors for CAC. Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.ConclusionThere is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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