• Tomasz Tykocki.
• Department of Paediatric Neurosurgery, Children's Hospital named after Prof. Jan Bogdanowicz in Warsaw, Warsaw, Poland; Maria Sklodowska-Curie Medical Academy, Warsaw, Poland. Electronic address: ttykocki@gmail.com.
• World Neurosurg. 2025 Jan 22; 194: 123579123579.

AbstractThis study explores the integration of chimeric antigen receptor T-cell (CAR-T) therapy with convection-enhanced delivery (CED) as a novel approach for treating diffuse intrinsic pontine glioma, a highly aggressive pediatric brain tumor with limited treatment options. Preliminary clinical results indicate that CED improves CAR-T cell distribution within the tumor microenvironment, leading to promising antitumor responses. However, challenges such as catheter-related complications and potential on-target/off-tumor toxicity remain. Ongoing research is essential to optimize these strategies and address ethical considerations surrounding patient safety and equitable access to innovative therapies. The aim is to assess the safety, efficacy, and distribution of CAR T cells delivered directly to the tumor site via CED, thereby enhancing therapeutic outcomes while minimizing systemic side effects.Copyright © 2025 The Author. Published by Elsevier Inc. All rights reserved.

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