Pharmacotherapy adjuncts for traumatic brain injury: A

Am J Emerg Med · Dec 2024

Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department.

Traumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.

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- Blake Robbins, Lars Almassalkhi, Regan Baum, Matthew Blackburn, Jason Davis, Lindsey Edwards, Garrett Hile, William Olney, Kyle Weant, and Elise Metts.
- University of Kentucky HealthCare, 800 Rose Street, Lexington, KY, 40536, USA. Electronic address: blake.robbins@uky.edu.
- Am J Emerg Med. 2024 Dec 8; 89: 788478-84.
AbstractTraumatic Brain Injury (TBI) remains a significant global health concern with significant impact on morbidity and mortality. This narrative review explores adjunctive pharmacologic agents to be employed by emergency medicine clinicians during Advanced Trauma Life Support (ATLS) in patients presenting with a TBI. Pharmacologic agents are commonly employed for the management of rapid sequence intubation and post-intubation analgosedation, hemodynamics, intracranial pressure, coagulopathy, seizure prophylaxis, and infection. This narrative review discusses current evidence and controversies to optimize adjunct pharmacotherapies during the acute management of TBI within the emergency department.Copyright © 2024. Published by Elsevier Inc.

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Pharmacotherapy adjuncts for traumatic brain injury: A narrative review of evidence and considerations in the emergency department.

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