• Neuroscience · Feb 2025

    Review

    Explaining neuronal membrane potentials: The Goldman equation vs. Lee's TELC hypothesis.

    • Todd P Silverstein.
    • Chemistry Department (emeritus), Willamette University, Salem, OR, USA.
    • Neuroscience. 2025 Feb 16; 567: 181-8.

    AbstractIn two recent papers (Curr Trends Neurol 17: 83-98, 2023; J Neurophysiol 124: 1029-1044, 2020), James Lee has argued that his Transmembrane Electrostatically-Localized Cations (TELC) hypothesis offers a model of neuron transmembrane potentials that is superior to Hodgkin-Huxley classic cable theory and the Goldman-Hodgkin-Katz (GHK) equation. Here we examine critically the arguments in these papers, finding key weaknesses and fallacies. We also examine closely the literature cited by Lee, and find (i) strong support for the GHK equation; (ii) published measurements that contradict TELC predictions; and (iii) no convincing support for the TELC hypothesis.Copyright © 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

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