• Neuroscience · Jan 2025

    High-order network degree revealed shared and distinct features among schizophrenia, bipolar disorder and ADHD.

    • Dingjie Wu, Zhao Chang, Yaozu Wang, Zhengchang Jiang, Rong Wang, and Ying Wu.
    • School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an, China; State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an, China.
    • Neuroscience. 2025 Jan 2; 568: 154165154-165.

    AbstractSchizophrenia (SCHZ), bipolar disorder (BD), and attention-deficit/hyperactivity disorder (ADHD) share clinical symptoms and risk genes, but the shared and distinct neural dynamic mechanisms at adults remain inadequately understood. Degree is a fundamental and important graph measure in network neuroscience, and we here used eigenmodes to extend the degree to hierarchical levels and compared the resting-state brain networks of three disorders and healthy controls (HC) at adults (age: 21-50 years old). First, compared to HC, SCHZ and BD patients exhibited substantially overlapped abnormalities in brain networks, wherein BD patients displayed more significant alterations. In contrast, ADHD patients exhibited few alterations. Second, compared to the graph theory measure, hierarchical degree better predicted the clinical symptoms of three disorders, and distinguished them from HC. Furthermore, three disorders shared associations of brain network abnormalities with dopamine receptors/transporters. Finally, the alterations in SCHZ and BD patients were associated with cellular localization and transport, as well as abnormal social behavior and communication, while ADHD patients were associated with energy production and transport. These findings provided a deep understanding of the shared and distinct neuropathology of three disorders and facilitated a more precise differentiation for them.Copyright © 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.